In season 2 of the NOCE Dose we examine how Opioid Use Disorder (OUD) impacts specific population groups that experience distinctive health vulnerabilities, including youth, older adults, individuals with disabilities and neurodivergence, birthing women and Tribal Nations. Anchored in evidence-based frameworks for trauma-informed care, developmental risk, and structural competency, the season prioritizes the integration of firsthand narratives with the data on service gaps. Listeners will engage in structured dialogue to better understand how variations in age, ability, neurodevelopment, and community context influence OUD risk trajectories and access to care. This season supports a broader objective of informing service models that are integrity-based, developmentally appropriate, and community-informed, consistent with national public health guidance for behavioral health fairness.